The ERCC6L Polyclonal Antibody (CAB6139) is a valuable tool for researchers studying ERCC6L, a protein involved in DNA repair and maintenance. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the ERCC6L protein, this antibody allows for the detection and analysis of ERCC6L in a variety of cell types, making it an essential component for studies in genetics and cancer research.ERCC6L, also known as DNA excision repair protein ERCC-6-like, is a crucial player in the repair of DNA damage caused by environmental factors and normal cellular processes.
Mutations in the ERCC6L gene have been linked to various diseases including cancer, highlighting the importance of understanding its function and regulation. Research on ERCC6L could lead to the development of targeted therapies for cancer and other genetic disorders, making this antibody a valuable asset for scientists working in these fields.
Product Name:
ERCC6L Rabbit Polyclonal Antibody
SKU:
CAB6139
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human ERCC6L (NP_060139.2).
This gene encodes a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF2) family of proteins, and contains a SNF2-like ATPase domain and a PICH family domain. One distinguishing feature of this SWI/SNF protein family member is that during interphase, the protein is excluded from the nucleus, and only associates with chromatin after the nuclear envelope has broken down. This protein is a DNA translocase that is thought to bind double-stranded DNA that is exposed to stretching forces, such as those exerted by the mitotic spindle. This protein associates with ribosomal DNA and ultra-fine DNA bridges (UFBs), fine structures that connect sister chromatids during anaphase at some sites such as fragile sites, telomeres and centromeres. This gene is required for the faithful segregation of sister chromatids during mitosis, and the ATPase activity of this protein required for the resolution of UFBs before cytokinesis.
Purification Method:
Affinity purification
Gene ID:
54821
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ERCC6L antibody (CAB6139) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
