ERCC6L Rabbit Polyclonal Antibody (CAB6139)
- SKU:
- CAB6139
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
Product Name: | ERCC6L Rabbit Polyclonal Antibody |
SKU: | CAB6139 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human ERCC6L (NP_060139.2). |
Sequence: | KDAT PGEK ALGF KISE NLMA IIKP YFLR RTKE DVQK KKSS NPEA RLNE KNPD VDAI CEMP SLSR KNDL IIWI RLVP LQEE IYRK FVSL DHIK ELLM ETRS P |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | PICH; RAD26L; ERCC6L |
Positive Sample: | 293T,Jurkat,A-549 |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, centromere, kinetochore. |
Calculated MW: | 141kDa |
Observed MW: | 223kDa |
This gene encodes a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF2) family of proteins, and contains a SNF2-like ATPase domain and a PICH family domain. One distinguishing feature of this SWI/SNF protein family member is that during interphase, the protein is excluded from the nucleus, and only associates with chromatin after the nuclear envelope has broken down. This protein is a DNA translocase that is thought to bind double-stranded DNA that is exposed to stretching forces, such as those exerted by the mitotic spindle. This protein associates with ribosomal DNA and ultra-fine DNA bridges (UFBs), fine structures that connect sister chromatids during anaphase at some sites such as fragile sites, telomeres and centromeres. This gene is required for the faithful segregation of sister chromatids during mitosis, and the ATPase activity of this protein required for the resolution of UFBs before cytokinesis.
Purification Method: | Affinity purification |
Gene ID: | 54821 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |