The ERCC6 Polyclonal Antibody (CAB18211) is a valuable tool for researchers studying ERCC6, a gene involved in DNA repair and transcription. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for Western blot applications. By binding to the ERCC6 protein, this antibody enables the detection and analysis of ERCC6 expression in various cell types, making it ideal for research in molecular biology and genomics.ERCC6, also known as Cockayne syndrome protein B (CSB), plays a crucial role in maintaining genomic stability by repairing DNA damage and promoting accurate transcription.
Dysfunction of ERCC6 is associated with Cockayne syndrome, a rare genetic disorder characterized by sensitivity to sunlight and premature aging. Research on ERCC6 is essential for understanding the mechanisms of DNA repair and transcription, as well as developing treatments for genetic diseases and cancer.Overall, the ERCC6 Polyclonal Antibody is a valuable tool for studying the functions of ERCC6 in various biological processes and disease states, providing insights into DNA repair mechanisms and potential therapeutic targets.
Product Name:
ERCC6 Rabbit Polyclonal Antibody
SKU:
CAB18211
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 700-800 of human ERCC6 (NP_000115.1).
This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between a splice site from exon 5 of this gene to the 3' splice site upstream of the open reading frame (ORF) of the adjacent gene, piggyback-derived-3 (GeneID:267004), which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene.
Purification Method:
Affinity purification
Gene ID:
2074
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using ERCC6 Rabbit pAb (CAB18211) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
