The ERCC3 Polyclonal Antibody (CAB1714) is a valuable tool for researchers studying ERCC3, a protein involved in DNA repair and maintenance. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By targeting the ERCC3 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for research in fields such as genetics, oncology, and molecular biology.ERCC3, also known as Xeroderma pigmentosum group B (XPB) protein, plays a critical role in repairing damaged DNA caused by exposure to ultraviolet (UV) light and other environmental factors.
Mutations in the ERCC3 gene are associated with various genetic disorders, including xeroderma pigmentosum, which leads to increased susceptibility to skin cancer. Understanding the function of ERCC3 is essential for advancing our knowledge of DNA repair mechanisms and developing targeted therapies for genetic diseases and cancer.
Product Name:
ERCC3 Rabbit Polyclonal Antibody
SKU:
CAB1714
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 513-782 of human ERCC3 (NP_000113.1).
This gene encodes an ATP-dependent DNA helicase that functions in nucleotide excision repair. The encoded protein is a subunit of basal transcription factor 2 (TFIIH) and, therefore, also functions in class II transcription. Mutations in this gene are associated with Xeroderma pigmentosum B, Cockayne's syndrome, and trichothiodystrophy. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2071
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ERCC3 antibody (CAB1714) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
