The ERCC3 Polyclonal Antibody (CAB12702) is a valuable tool for researchers studying ERCC3, a gene involved in DNA repair and maintenance. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. By binding to the ERCC3 protein, this antibody enables researchers to detect and analyze the expression levels of ERCC3 in various cell types.ERCC3, also known as Xeroderma pigmentosum group B-complementing protein, is involved in the nucleotide excision repair pathway, which helps to remove DNA damage caused by UV radiation and other environmental factors.
Understanding the role of ERCC3 in DNA repair is important for studying diseases such as xeroderma pigmentosum and certain types of cancer, where mutations in this gene can lead to increased susceptibility to DNA damage.With its high specificity and reactivity in human samples, the ERCC3 Polyclonal Antibody (CAB12702) is a valuable tool for researchers investigating the role of ERCC3 in DNA repair mechanisms and its implications for human health and disease.
Product Name:
ERCC3 Rabbit Polyclonal Antibody
SKU:
CAB12702
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 512-782 of human ERCC3 (NP_000113.1).
This gene encodes an ATP-dependent DNA helicase that functions in nucleotide excision repair. The encoded protein is a subunit of basal transcription factor 2 (TFIIH) and, therefore, also functions in class II transcription. Mutations in this gene are associated with Xeroderma pigmentosum B, Cockayne's syndrome, and trichothiodystrophy. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2071
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ERCC3 Rabbit pAb (CAB12702) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
