XPD/ERCC2 Rabbit Polyclonal Antibody (CAB14563)
- SKU:
- CAB14563
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | XPD/ERCC2 Rabbit Polyclonal Antibody |
SKU: | CAB14563 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human XPD/XPD/ERCC2 (NP_001124339.1). |
Sequence: | MREL KRTL DAKG HGVL EMPS GTGK TVSL LALI MAYQ RAYP LEVT KLIY CSRT VPEI EKVI EELR KLLN FYEK QEGE KLPF LGLA LSSR KNLC IHPE VTPL RFGK DVDG KCHS LTAS YVRA QYQH DTSL PHCR FYEE FDAH GREV PLPA GIYN LDDL KALG RRQG WCPY FLAR YSIL HANV |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | EM9; TTD; XPD; TTD1; COFS2; TFIIH; XPD/ERCC2 |
Positive Sample: | HeLa,293T,Mouse testis,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, cytoskeleton, spindle. |
Calculated MW: | 87kDa |
Observed MW: | 80kDa |
The nucleotide excision repair pathway is a mechanism to repair damage to DNA. The protein encoded by this gene is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. The gene product has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in this gene can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 2068 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |