The Erbin Polyclonal Antibody (CAB8585) offered by Assay Genie is a valuable tool for researchers studying Erbin, a protein known for its involvement in cellular signaling pathways and regulation of cell growth and differentiation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards Erbin in human samples, making it suitable for use in Western blot applications.Erbin, a scaffold protein found in various tissues, plays a crucial role in the modulation of cell-cell adhesion and cell polarity, making it a key player in processes like cell migration and tissue organization.
Its dysregulation has been implicated in various diseases, including cancer and neurological disorders, highlighting the importance of studying its function and mechanisms of action.By targeting Erbin with this polyclonal antibody, researchers can gain insights into its role in cellular processes and disease pathways, paving the way for the development of novel therapeutic strategies targeting Erbin-related disorders. Whether investigating Erbin's function in normal physiology or disease states, this antibody provides a powerful tool for advancing research in cell biology, cancer biology, and beyond.
Product Name:
ERBB2IP Rabbit Polyclonal Antibody
SKU:
CAB8585
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1152-1371 of human ERBB2IP (NP_061165.1).
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
55914
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ERBB2IP antibody (CAB8585) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
