The ERBB4 Rabbit Monoclonal Antibody (CAB19047) is a crucial tool for researchers studying the ERBB4 protein, a receptor tyrosine kinase linked to various signaling pathways and implicated in multiple cellular functions. This antibody, developed in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to ERBB4, this antibody enables precise detection and analysis of the protein in different cell types, making it a valuable asset for studies in cancer biology and signaling cascades.ERBB4, also known as HER4, is a member of the epidermal growth factor receptor family and is associated with cell proliferation, differentiation, and survival.
Dysregulation of ERBB4 signaling has been linked to various cancers and developmental disorders, highlighting the importance of understanding its function in normal and diseased states. The ERBB4 Rabbit Monoclonal Antibody provides researchers with a reliable tool for investigating the role of ERBB4 in cellular processes and disease pathways, ultimately paving the way for the development of targeted therapies and treatments.
Product Name:
ErbB4/HER4 Rabbit Monoclonal Antibody
SKU:
CAB19047
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1200-1308 of human ErbB4/HER4 (Q15303).
Cell membrane, Mitochondrion, Nucleus, Single-pass type I membrane protein.
Calculated MW:
147kDa
Observed MW:
200kDa
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Purification Method:
Affinity purification
Gene ID:
2066
Clone Number:
ARC2639
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ErbB4/HER4 antibody (CAB19047) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
