The ERBB4 Polyclonal Antibody (CAB6133) is a valuable tool for researchers studying the ERBB4 protein, a receptor tyrosine kinase involved in cell growth and differentiation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By binding specifically to the ERBB4 protein, researchers can accurately detect and analyze its expression levels in a variety of cell types.ERBB4, also known as HER4, is a crucial player in signal transduction pathways that regulate cell proliferation and survival.
Dysregulation of ERBB4 has been linked to various diseases, including cancer. By understanding the role of ERBB4 in cellular processes, researchers can gain insights into potential therapeutic targets for cancer treatment and other related conditions.Overall, the ERBB4 Polyclonal Antibody is a reliable tool for investigating the function of the ERBB4 protein in different biological contexts, making it a valuable asset for studies in cancer research and beyond.
Product Name:
ErbB4/HER4 Rabbit Polyclonal Antibody
SKU:
CAB6133
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1150-1250 of human ErbB4/HER4 (NP_005226.1).
Cell membrane, Mitochondrion, Nucleus, Single-pass type I membrane protein.
Calculated MW:
147kDa
Observed MW:
180kDa
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Purification Method:
Affinity purification
Gene ID:
2066
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse brain, using ErbB4/HER4 Rabbit pAb (CAB6133) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 10s.
