ErbB4/HER4 Rabbit Polyclonal Antibody (CAB0749)
- SKU:
- CAB0749
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Description
Product Name: | ErbB4/HER4 Rabbit Polyclonal Antibody |
SKU: | CAB0749 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1150-1250 of human ErbB4/HER4 (NP_005226.1). |
Sequence: | YMTP MRDK PKQE YLNP VEEN PFVS RRKN GDLQ ALDN PEYH NASN GPPK AEDE YVNE PLYL NTFA NTLG KAEY LKNN ILSM PEKA KKAF DNPD YWNH SLPP R |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | HER4; ALS19; p180erbB4; ErbB4/HER4 |
Positive Sample: | Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Mitochondrion, Nucleus, Single-pass type I membrane protein. |
Calculated MW: | 147kDa |
Observed MW: | 147kDa |
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Purification Method: | Affinity purification |
Gene ID: | 2066 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |