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ERBB2 Monoclonal Antibody [P7H3BV] (CPAB0104)

SKU:
CPAB0104
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Clone:
P7H3BV
Applications:
WB
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

ERBB2 Monoclonal Antibody [P7H3BV] (CPAB0104)

The ERBB2 Polyclonal Antibody (CPAB0104) is a key tool for researchers studying ERBB2, a receptor tyrosine kinase involved in cell growth and survival. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the ERBB2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential resource for investigations in oncology and cell biology.ERBB2, also known as HER2, plays a crucial role in promoting cell proliferation and inhibiting apoptosis, making it a significant target in cancer research.

Aberrant expression of ERBB2 is implicated in various cancers, including breast cancer, making it a focus for developing targeted therapies. Understanding the function and regulation of ERBB2 is essential for advancing treatments and improving patient outcomes in cancer care.Overall, the ERBB2 Polyclonal Antibody (CPAB0104) offers researchers a reliable tool for studying ERBB2 and its role in cell signaling and cancer development. Its high specificity and sensitivity make it a valuable asset for elucidating the mechanisms of ERBB2-mediated pathways and identifying potential therapeutic targets for cancer treatment.

Product Name:ERBB2 Antibody
Product Sku:CPAB0104
Size:5μg
Host Species:
Immunogen:Anti-human ErbB2 mAb, is derived from mice immunized with the recombinant human ErbB2 (43.4 kDa, 397 a.aand one extra N-terminal Methionin) purified from Ecoli.
Clone:P7H3BV.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:
Isotype:
Background:HER-2/neu (erbB-2) encodes an 185-kDa orphan receptor tyrosine kinase that is constitutively active as a dimer and displays potent oncogenic activity when overexpressed. Herstatin, as the product of alternative HER-2 transcript, retains intron 8. The herstatin mRNA is expressed in normal human fetal kidney and liver, but is at reduced levels relative to p185HER-2 mRNA in carcinoma cells that contain an amplified HER-2 gene. Herstatin appears to be an inhibitor of p185HER-2, because it disrupts dimers, reduces tyrosine phosphorylation of p185, and inhibits the anchorage-independent growth of transformed cells that overexpress HER-2.
Synonyms:NEU, NGL, HER2, TKR1, HER-2, c-erb B2, HER-2/neu, Receptor tyrosine-protein kinase erbB-2, EC 2.7.10.1, p185erbB2, C-erbB-2, NEU proto-oncogene, Tyrosine kinase-type cell surface receptor HER2, MLN 19, CD340 antigen.
Storage Buffer:

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