The ERAS Polyclonal Antibody (PAC023437) is a valuable tool for researchers studying the ERAS protein, which is known for its role in promoting tumor growth and metastasis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.ERAS, a member of the RAS oncogene family, is implicated in various cellular processes, including cell proliferation, differentiation, and survival. Its overexpression has been linked to tumorigenesis, making it a promising target for cancer research. By binding to the ERAS protein, this antibody enables researchers to detect and analyze its expression levels in different cell types, providing valuable insights for studies in oncology and molecular biology.
Understanding the function of ERAS is crucial for developing targeted therapies to inhibit its activity and potentially disrupt cancer progression. By utilizing the ERAS Polyclonal Antibody, researchers can further elucidate the mechanisms by which this protein contributes to tumorigenesis, paving the way for the development of novel treatment strategies for cancer patients.
Synthesized peptide derived from C-terminal of human ERAS.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from Jurkat cells, using ERAS antibody.
Immunofluorescence analysis of A549 cells, using ERAS antibody.
Background:
Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells By similarity.
ERas: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the tumor-like growth properties of embryonic stem cells. Belongs to the small GTPase superfamily. Ras family.Protein type: G protein, monomeric, Ras; G protein, monomeric; G proteinChromosomal Location of Human Ortholog: Xp11.23
UniProt Protein Details:
NCBI Summary:
This gene encodes a constitutively active member of the small GTPase Ras protein family. The encoded protein activates the phosphatidylinositol 3-kinase signal transduction pathway in undifferentiated stem cells, but is not expressed in differentiated cells. This gene may be involved in cancer and chemotherapy resistance. [provided by RefSeq, Dec 2012]
