The ERAP2 Polyclonal Antibody (CAB9024) is a valuable tool for researchers studying ERAP2, an enzyme involved in antigen processing and presentation. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the ERAP2 protein, researchers can effectively detect and analyze its expression in various cell types, making this antibody essential for studies in immunology and oncology research.ERAP2, also known as ER aminopeptidase 2, plays a crucial role in shaping the antigenic peptide repertoire presented by major histocompatibility complex (MHC) class I molecules.
This process is essential for immune surveillance and response against pathogens, making ERAP2 a key player in the immune system. Research into ERAP2 function is vital for understanding immune responses in conditions such as viral infections, autoimmune diseases, and cancer.By using the ERAP2 Polyclonal Antibody, researchers can deepen their understanding of the role of ERAP2 in antigen processing and its implications for immune system function. This knowledge is essential for the development of targeted therapies and vaccines that leverage the immune response for the treatment of various diseases.
Product Name:
ERAP2 Rabbit Polyclonal Antibody
SKU:
CAB9024
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human ERAP2 (NP_071745.1).
Endoplasmic reticulum membrane, Single-pass type II membrane protein.
Calculated MW:
110kDa
Observed MW:
110kDa
This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5.
Purification Method:
Affinity purification
Gene ID:
64167
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ERAP2 Rabbit pAb (CAB9024) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
