The ERAP1 Polyclonal Antibody (CAB5978) is a valuable tool for researchers studying endoplasmic reticulum aminopeptidase 1 (ERAP1), an enzyme involved in antigen processing and presentation. This antibody, raised in rabbits, exhibits high reactivity with ERAP1 in human samples and has been validated for use in Western blot applications.ERAP1 plays a crucial role in the trimming of peptides for major histocompatibility complex (MHC) class I molecules, impacting the immune response and defense against infections.
Dysregulation of ERAP1 has been associated with various autoimmune diseases, making it a promising target for therapeutic interventions.By using the ERAP1 Polyclonal Antibody, researchers can accurately detect and analyze ERAP1 expression in different cell types, providing valuable insights into its function and potential as a therapeutic target. This antibody is an essential tool for studies in immunology, autoimmunity, and infectious diseases, contributing to the advancement of knowledge in these fields.
Product Name:
ERAP1 Rabbit Monoclonal Antibody
SKU:
CAB5978
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 842-941 of human ERAP1 (Q9NZ08).
The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
51752
Clone Number:
ARC2120
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using ERAP1 Rabbit mAb (CAB5978) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
