The ERAL1 Polyclonal Antibody (CAB10382) is a valuable tool for research involving ERAL1, a protein involved in mitochondrial ribosome biogenesis and tRNA modification. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It binds to the ERAL1 protein, allowing for the detection and analysis of ERAL1 in various cell types, making it ideal for studies in molecular biology and mitochondrial dysfunction research.ERAL1 is a key player in maintaining mitochondrial function and is crucial for the proper functioning of the mitochondrial ribosomes.
Dysregulation of ERAL1 has been implicated in various diseases, including mitochondrial disorders and cancer. Understanding the role of ERAL1 in cellular processes is fundamental for advancing research in these areas and developing targeted therapies. The ERAL1 Polyclonal Antibody provides researchers with a reliable tool to study ERAL1 and its functions, leading to further insights into mitochondrial biology and disease pathology.
Product Name:
ERAL1 Rabbit Polyclonal Antibody
SKU:
CAB10382
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 198-437 of human ERAL1 (NP_005693.1).
The protein encoded by this gene is a GTPase that localizes to the mitochondrion. The encoded protein binds to the 3' terminal stem loop of 12S mitochondrial rRNA and is required for proper assembly of the 28S small mitochondrial ribosomal subunit. Deletion of this gene has been shown to cause mitochondrial dysfunction, growth retardation, and apoptosis. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
26284
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ERAL1 Rabbit pAb (CAB10382) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
