The Epoxide Hydrolase 1 Polyclonal Antibody (CAB2070) is a valuable tool for researchers studying epoxide hydrolase 1, an enzyme involved in the metabolism of various compounds, including xenobiotics and endogenous lipid mediators. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for use in Western blotting applications.Epoxide hydrolase 1 plays a crucial role in the detoxification and elimination of potentially harmful epoxides, thereby protecting cells and tissues from damage. Dysregulation of this enzyme has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular conditions.
By targeting epoxide hydrolase 1, researchers can gain insights into the mechanisms underlying these diseases and explore potential therapeutic interventions.With its ability to detect and quantify epoxide hydrolase 1 expression in different cell types, the CAB2070 antibody is an invaluable asset for studies in pharmacology, toxicology, and drug development. By elucidating the role of this enzyme in health and disease, researchers can pave the way for the development of novel treatments and interventions targeting epoxide metabolism.
Product Name:
EPHX1 Rabbit Polyclonal Antibody
SKU:
CAB2070
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-320 of human EPHX1 (NP_000111.1).
Endoplasmic reticulum membrane, Microsome membrane, Single-pass type II membrane protein.
Calculated MW:
53kDa
Observed MW:
48kDa
Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2052
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using EPHX1 antibody (CAB2070) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
