EPOR Rabbit Polyclonal Antibody (CAB2917)
- SKU:
- CAB2917
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | EPOR Rabbit Polyclonal Antibody |
SKU: | CAB2917 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 274-508 of human EPOR (NP_000112.1). |
Sequence: | HRRA LKQK IWPG IPSP ESEF EGLF TTHK GNFQ LWLY QNDG CLWW SPCT PFTE DPPA SLEV LSER CWGT MQAV EPGT DDEG PLLE PVGS EHAQ DTYL VLDK WLLP RNPP SEDL PGPG GSVD IVAM DEGS EASS CSSA LASK PSPE GASA ASFE YTIL DPSS QLLR PWTL CPEL PPTP PHLK YLYL VVSD SGIS TDYS SGDS QGAQ GGLS DGPY SNPY ENSL IPAA EPLP PSYV ACS |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | EPO-R; EPOR |
Positive Sample: | Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Secreted, Single-pass type I membrane protein. |
Calculated MW: | 55kDa |
Observed MW: | 60kDa |
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 2057 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |