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EPHB1/EPHB2/EPHB3/EPHB4 Antibody (PACO02656)

SKU:
PACO02656
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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EPHB1/EPHB2/EPHB3/EPHB4 Antibody (PACO02656)

The EphB1/EphB2/EphB3/EphB4 Polyclonal Antibody (PACO02656) is a versatile tool designed for researchers studying the EphB family of receptor tyrosine kinases. These proteins play key roles in diverse cellular processes, including cell adhesion, migration, and axon guidance. The antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.By targeting the EphB1, EphB2, EphB3, and EphB4 proteins, this antibody enables precise detection and analysis in a variety of cell types. Its specificity for the EphB family makes it ideal for investigations in developmental biology, neurobiology, and cancer research.

The ability to accurately assess the expression levels and localization of these receptors is essential for understanding their functions and potential therapeutic applications.The EphB1/EphB2/EphB3/EphB4 Polyclonal Antibody (PACO02656) is a valuable tool for researchers seeking to unravel the complex signaling mechanisms mediated by the EphB family in both normal and pathological conditions. By elucidating the functions of these receptors, we can gain insights into their roles in disease progression and identify novel targets for therapeutic intervention.

Antibody Name:EPHB1/EPHB2/EPHB3/EPHB4 Antibody
Antibody SKU:PACO02656
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from human EphB1/2/3/4 around the non-phosphorylation site of Y600/602/614/596.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:EPHB1; ELK; EPHT2; HEK6; NET; Ephrin type-B receptor 1; ELK; EPH tyrosine kinase 2; EPH-like kinase 6; EK6; hEK6; Neuronally-expressed EPH-related tyrosine kinase; NET; Tyrosine-protein kinase receptor EPH-2; EPHB2; DRT; EPHT3; EPTH3; ERK;
UniProt Protein Function:EphB1: a receptor tyrosine kinase of the Eph family. Receptor for members of the ephrin-B family: ephrin-B1, -B2 and -B3. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. The ligand-activated form of EphB1 interacts with GRB2, GRB10 and NCK through their respective SH2 domains. Four alternatively spliced isoforms are known.
UniProt Protein Details:

Protein type:Protein kinase, TK; Kinase, protein; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; TK group; Eph family

Chromosomal Location of Human Ortholog: 3q21-q23

Cellular Component: cytosol; early endosome membrane; extracellular region; integral to plasma membrane; plasma membrane

Molecular Function:protein binding; transmembrane-ephrin receptor activity

Biological Process: angiogenesis; axon guidance; cell-substrate adhesion; central nervous system projection neuron axonogenesis; detection of temperature stimulus involved in sensory perception of pain; ephrin receptor signaling pathway; establishment of cell polarity; neurogenesis; positive regulation of synaptogenesis; protein amino acid autophosphorylation; regulation of JNK cascade; retinal ganglion cell axon guidance

NCBI Summary:Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]
UniProt Code:P54762
NCBI GenInfo Identifier:1706663
NCBI Gene ID:2047
NCBI Accession:P54762.1
UniProt Secondary Accession:P54762,O43569, O95142, O95143, Q0VG87, A8K593, B3KTB2 B5A969,
UniProt Related Accession:P54762
Molecular Weight:26,906 Da
NCBI Full Name:Ephrin type-B receptor 1
NCBI Synonym Full Names:EPH receptor B1
NCBI Official Symbol:EPHB1  
NCBI Official Synonym Symbols:ELK; NET; Hek6; EPHT2  
NCBI Protein Information:ephrin type-B receptor 1
UniProt Protein Name:Ephrin type-B receptor 1
UniProt Synonym Protein Names:ELK; EPH tyrosine kinase 2; EPH-like kinase 6; EK6; hEK6; Neuronally-expressed EPH-related tyrosine kinase; NET; Tyrosine-protein kinase receptor EPH-2
Protein Family:Ephrin type-B receptor
UniProt Gene Name:EPHB1  
UniProt Entry Name:EPHB1_HUMAN

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