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EPHB1/EPHB2/EPHB3 Antibody (PACO03626)

SKU:
PACO03626
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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EPHB1/EPHB2/EPHB3 Antibody (PACO03626)

The EphB1/EphB2/EphB3 Polyclonal Antibody (PAC003626) is a valuable tool for researchers studying the Eph receptor family, specifically EphB1, EphB2, and EphB3. These cell surface receptors play important roles in cell signaling, development, and tissue homeostasis. Raised in rabbits, this antibody is highly reactive with human samples and has been validated for use in Western blot applications. It binds specifically to EphB1, EphB2, and EphB3 proteins, allowing for the detection and analysis of these receptors in a variety of cell types. This makes it an ideal choice for studies in developmental biology, neuroscience, and cancer research.

The Eph receptors are known to be involved in a wide range of biological processes, including cell migration, adhesion, and differentiation. Dysregulation of Eph receptor signaling has been implicated in various diseases, making them attractive targets for therapeutic intervention. By understanding the role of EphB1, EphB2, and EphB3 in cell signaling and development, researchers can gain valuable insights into disease mechanisms and potentially identify new therapeutic strategies.

Antibody Name:EPHB1/EPHB2/EPHB3 Antibody
Antibody SKU:PACO03626
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC, IF
Recommended Dilutions:IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from the Internal region of human EphB1/2/3.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:EPHB1; ELK; EPHT2; HEK6; NET; Ephrin type-B receptor 1; ELK; EPH tyrosine kinase 2; EPH-like kinase 6; EK6; hEK6; Neuronally-expressed EPH-related tyrosine kinase; NET; Tyrosine-protein kinase receptor EPH-2; EPHB2; DRT; EPHT3; EPTH3; ERK;
UniProt Protein Function:EphB1: a receptor tyrosine kinase of the Eph family. Receptor for members of the ephrin-B family: ephrin-B1, -B2 and -B3. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. The ligand-activated form of EphB1 interacts with GRB2, GRB10 and NCK through their respective SH2 domains. Four alternatively spliced isoforms are known.
UniProt Protein Details:

Protein type:Protein kinase, TK; Kinase, protein; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; TK group; Eph family

Chromosomal Location of Human Ortholog: 3q21-q23

Cellular Component: cytosol; early endosome membrane; extracellular region; integral to plasma membrane; plasma membrane

Molecular Function:protein binding; transmembrane-ephrin receptor activity

Biological Process: angiogenesis; axon guidance; cell-substrate adhesion; central nervous system projection neuron axonogenesis; detection of temperature stimulus involved in sensory perception of pain; ephrin receptor signaling pathway; establishment of cell polarity; neurogenesis; positive regulation of synaptogenesis; protein amino acid autophosphorylation; regulation of JNK cascade; retinal ganglion cell axon guidance

NCBI Summary:Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]
UniProt Code:P54762
NCBI GenInfo Identifier:1706663
NCBI Gene ID:2047
NCBI Accession:P54762.1
UniProt Secondary Accession:P54762,O43569, O95142, O95143, Q0VG87, A8K593, B3KTB2 B5A969,
UniProt Related Accession:P54762
Molecular Weight:26,906 Da
NCBI Full Name:Ephrin type-B receptor 1
NCBI Synonym Full Names:EPH receptor B1
NCBI Official Symbol:EPHB1  
NCBI Official Synonym Symbols:ELK; NET; Hek6; EPHT2  
NCBI Protein Information:ephrin type-B receptor 1
UniProt Protein Name:Ephrin type-B receptor 1
UniProt Synonym Protein Names:ELK; EPH tyrosine kinase 2; EPH-like kinase 6; EK6; hEK6; Neuronally-expressed EPH-related tyrosine kinase; NET; Tyrosine-protein kinase receptor EPH-2
Protein Family:Ephrin type-B receptor
UniProt Gene Name:EPHB1  
UniProt Entry Name:EPHB1_HUMAN

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