The EphA4 Polyclonal Antibody (CAB8346) is a crucial tool for researchers studying the EphA4 protein, a cell surface receptor involved in a variety of cellular processes. This antibody, generated in rabbits, exhibits high specificity and reactivity with EphA4 in human samples, making it ideal for Western blot applications. By targeting the EphA4 protein, this antibody enables precise detection and analysis of EphA4 expression in different cell types, making it an invaluable asset for investigations in neurobiology, development, and cancer research.EphA4 is a member of the Eph receptor tyrosine kinase family, known for its involvement in axon guidance, synaptic plasticity, and cell migration.
Dysregulation of EphA4 signaling has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, as well as cancer progression. Understanding the role of EphA4 in these processes is essential for developing targeted therapies and interventions that can potentially impact human health outcomes. Utilizing the EphA4 Polyclonal Antibody (CAB8346) in research can provide valuable insights into the function and signaling mechanisms of EphA4, paving the way for innovative treatments and diagnostic strategies in various disease contexts.
Product Name:
EPHA4 Rabbit Polyclonal Antibody
SKU:
CAB8346
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-100 of human EPHA4 (NP_004429.1).
Cell junction, Cell membrane, Cell projection, Early endosome, Single-pass type I membrane protein, axon, dendrite, postsynaptic cell membrane, postsynaptic density, synapse.
Calculated MW:
110kDa
Observed MW:
110kDa
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2043
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using EPHA4 antibody (CAB8346) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
