The EPGN Polyclonal Antibody (PAC019608) is a valuable tool for research involving EPGN, a cell surface protein involved in various cellular processes, including cell proliferation, differentiation, and survival. This antibody, derived from rabbit sources, exhibits high reactivity with human samples and has been validated for use in Western blot applications. It specifically recognizes the EPGN protein, allowing for accurate detection and analysis in different cell types, making it perfect for studies in cell biology and cancer research.EPGN, also known as epigen, plays a crucial role in regulating cell growth and survival, making it a potential target for therapeutic interventions in diseases such as cancer.
Its involvement in various cellular functions highlights the importance of studying its role in different physiological and pathological conditions. The EPGN Polyclonal Antibody provides researchers with a reliable tool to investigate the function and regulation of EPGN in order to expand our understanding of its implications in disease development and progression.
Antibody Name:
EPGN Antibody (PACO19608)
Antibody SKU:
PACO19608
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human EPGN
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Jurkat cells, 293T cells, hela cells, Primary antibody: PACO19608(EPGN Antibody) at dilution 1/150, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
Background:
The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants.
Synonyms:
epithelial mitogen
UniProt Protein Function:
Epigen: Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. 7 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinaseChromosomal Location of Human Ortholog: 4q13.3Cellular Component: extracellular space; integral to plasma membrane; intracellularMolecular Function: epidermal growth factor receptor binding; growth factor activityBiological Process: activation of MAPK activity; angiogenesis; epidermal growth factor receptor signaling pathway; MAPKKK cascade; positive regulation of cell proliferation; positive regulation of epidermal growth factor receptor activity; positive regulation of epithelial cell proliferation; positive regulation of MAP kinase activity; positive regulation of mitosis
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
