The EPGN Polyclonal Antibody (PACO06928) is a valuable tool for researchers studying the EPGN protein, a member of the epidermal growth factor (EGF) family that plays a crucial role in cell proliferation and differentiation. This antibody, produced in rabbits, is highly specific for human EPGN samples and has been validated for use in Western blot applications.EPGN is known for its involvement in various biological processes, including tissue development, wound healing, and cancer progression. By targeting the EPGN protein, researchers can investigate its function in different cell types and gain insights into its potential role in diseases such as cancer and developmental disorders.
With its high reactivity and specificity, the EPGN Polyclonal Antibody is a reliable tool for exploring the functions and mechanisms of EPGN in various research areas. Whether studying cell signaling pathways, gene expression regulation, or disease pathways, this antibody provides researchers with a valuable resource for their studies.
Antibody Name:
EPGN Antibody (PACO06928)
Antibody SKU:
PACO06928
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:10000, WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the Internal region of human Epigen.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of 293T 823 cells using Epigen Polyclonal Antibody.
Western Blot analysis of 293T cells using Epigen Polyclonal Antibody.
Synonyms:
EPGN; Epigen; Epithelial mitogen; EPG
UniProt Protein Function:
Epigen: Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. 7 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinaseChromosomal Location of Human Ortholog: 4q13.3Cellular Component: extracellular space; integral to plasma membrane; intracellularMolecular Function: epidermal growth factor receptor binding; growth factor activityBiological Process: activation of MAPK activity; angiogenesis; epidermal growth factor receptor signaling pathway; MAPKKK cascade; positive regulation of cell proliferation; positive regulation of epidermal growth factor receptor activity; positive regulation of epithelial cell proliferation; positive regulation of MAP kinase activity; positive regulation of mitosis
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
