The EPB42 Polyclonal Antibody (CAB17481) is a valuable tool for researchers studying EPB42, a protein involved in various cellular processes such as cell shape regulation and membrane stability. This antibody, raised in rabbits, is highly specific to EPB42 in human samples and is validated for use in Western blot applications. By binding to the EPB42 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for studies in cell biology and disease research.EPB42, also known as erythrocyte membrane protein band 4.2, is essential for maintaining the shape and function of red blood cells.
Mutations in the EPB42 gene have been linked to hereditary spherocytosis, a condition characterized by abnormally shaped red blood cells. Research into EPB42 can provide insights into the mechanisms underlying this disorder and potentially lead to the development of targeted therapies.Overall, the EPB42 Polyclonal Antibody (CAB17481) offers researchers a reliable tool for studying the function and implications of EPB42 in various biological contexts, advancing our understanding of cellular dynamics and disease pathology.
Product Name:
EPB42 Rabbit Polyclonal Antibody
SKU:
CAB17481
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 10-240 of human EPB42 (NP_001107606).
Erythrocyte membrane protein band 4.2 is an ATP-binding protein which may regulate the association of protein 3 with ankyrin. It probably has a role in erythrocyte shape and mechanical property regulation. Mutations in the EPB42 gene are associated with recessive spherocytic elliptocytosis and recessively transmitted hereditary hemolytic anemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2038
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using EPB42 antibody (CAB17481) at 1:800 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 45s.
