EP300 Polyclonal Antibody (CAB24352)
- SKU:
- CAB24352
Frequently bought together:
Description
| Product Name: | EP300 Polyclonal Antibody |
| SKU: | CAB24352 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Mouse,Rat |
| Immunogen: | Recombinant Protein corresponding to a sequence within amino acids 940-1030 of human EP300(NP_001420.2). |
| Sequence: | LSQP AVSI EGQV SNPP STSS TEVN SQAI AEKQ PSQE VKME AKME VDQP EPAD TQPE DISE SKVE DCKM ESTE TEER STEL KTEI KEEE DQP |
| Tested Applications: | IHC-P ELISA |
| Recommended Dilution: | IHC-P,1:50 - 1:200 |
| Synonyms: | p300; KAT3B; MKHK2; RSTS2; EP300 |
| Conjugate: | Unconjugated |
| Cellular Localization: | Cytoplasm, Nucleus. |
| Calculated MW: | 264kDa |
| Observed MW: | Refer to figures |
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
| Purification Method: | Affinity purification |
| Gene ID: | 2033 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |
 | Immunohistochemistry analysis of EP300 in paraffin-embedded rat colon tissue using EP300 Rabbit pAb (CAB24352) at a dilution of 1:100 (40x lens). High pressure antigen retrieval was performed with 0.01 M citrate buffer (pH 6.0) prior to IHC staining. |
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