The EP300 Polyclonal Antibody (CAB13016) is a valuable tool for researchers studying EP300, a key protein involved in gene regulation and chromatin remodeling. This antibody, produced in rabbits, shows high reactivity with human samples and has been validated for use in applications such as Western blotting. By targeting the EP300 protein, this antibody allows for the detection and analysis of EP300 in a variety of cell types, making it ideal for studies in molecular biology, cancer research, and epigenetics.EP300 is a histone acetyltransferase that plays a crucial role in gene transcription, cell differentiation, and DNA repair processes.
Dysregulation of EP300 has been linked to various diseases, including cancer, neurodevelopmental disorders, and cardiovascular diseases. Therefore, understanding the function and regulation of EP300 is essential for developing targeted therapies and novel treatments for these conditions.Overall, the EP300 Polyclonal Antibody (CAB13016) provides researchers with a powerful tool for investigating the role of EP300 in various biological processes and diseases, offering new insights into potential therapeutic targets and treatment strategies.
Product Name:
EP300 Rabbit Polyclonal Antibody
SKU:
CAB13016
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human EP300 (NP_001420.2).
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
Purification Method:
Affinity purification
Gene ID:
2033
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human esophageal cancer using EP300 Rabbit pAb (CAB13016) at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
