EP300 Rabbit Polyclonal Antibody (CAB13016)
- SKU:
- CAB13016
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | EP300 Rabbit Polyclonal Antibody |
SKU: | CAB13016 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human EP300 (NP_001420.2). |
Sequence: | MAEN VVEP GPPS AKRP KLSS PALS ASAS DGTD FGSL FDLE HDLP DELI NSTE LGLT NGGD INQL QTSL GMVQ DAAS KHKQ LSEL LRSG SSPN LNMG VGGP GQVM ASQA QQSS PGLG LINS MVKS PMTQ AGLT SPNM GMGT SGPN QGPT QSTG MMNS PVNQ PAMG MNTG MNAG MNPG MLAA GNGQ GIMP NQVM NGSI GAGR GRQN MQYP NPGM GSAG NLLT EPLQ QGSP QMGG QTGL RGPQ PLKM GMMN NPNP YGSP YTQN PGQQ IGAS GL |
Tested Applications: | IHC-P IF/ICC ELISA |
Recommended Dilution: | IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | p300; KAT3B; MKHK2; RSTS2; EP300 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 264kDa |
Observed MW: | Refer to figures |
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.
Purification Method: | Affinity purification |
Gene ID: | 2033 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |