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Eotaxin-1 monoclonal antibody (AGIM0014)

SKU:
AGIM0014
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
hEOT1
Conjugation:
Unconjugated
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:Eotaxin-1 monoclonal antibody
Product Code:AGIM0014
Size:100 µg in 100 µL
Reactivity:Human
Clone:hEOT1
Applications:Flow Cytometry
Conjugate:Unconjugated
Isotype:IgG1
Host Species:Mouse
Storage:Storage conditions:Store at 4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.
Uniprot:P51671
Background:Eotaxin is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN- ?? timulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and along Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung, and in allergic reactions.
UniProt Protein Function:CCL11: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular region; extracellular space; intracellular

Molecular Function:CCR chemokine receptor binding; chemokine activity; protein binding

Biological Process: actin filament organization; cell adhesion; cellular calcium ion homeostasis; chemotaxis; chronic inflammatory response; cytoskeleton organization and biogenesis; eosinophil chemotaxis; G-protein coupled receptor protein signaling pathway; inflammatory response; lymphocyte chemotaxis; mast cell chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of actin filament polymerization; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of inflammatory response; protein amino acid phosphorylation; regulation of cell shape; response to radiation; response to virus; signal transduction

Disease: Asthma, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To

NCBI Summary:This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]
UniProt Code:P51671
NCBI GenInfo Identifier:1706661
NCBI Gene ID:6356
NCBI Accession:P51671.1
UniProt Secondary Accession:P51671,P50877, Q92490, Q92491,
UniProt Related Accession:P51671
Molecular Weight:10,732 Da
NCBI Full Name:Eotaxin
NCBI Synonym Full Names:C-C motif chemokine ligand 11
NCBI Official Symbol:CCL11  
NCBI Official Synonym Symbols:SCYA11  
NCBI Protein Information:eotaxin
UniProt Protein Name:Eotaxin
UniProt Synonym Protein Names:C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11
Protein Family:Eotaxin
UniProt Gene Name:CCL11  
UniProt Entry Name:CCL11_HUMAN

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