The ENY2 Polyclonal Antibody (PAC04214) is a valuable tool for researchers studying ENY2, a protein involved in various cellular processes such as transcription regulation and DNA repair. The antibody, produced in rabbits, is highly specific for human ENY2 and is suitable for use in Western blotting and immunohistochemistry experiments. By binding to ENY2, this antibody allows for the detection and analysis of the protein in different cell types, making it an essential component for studies in molecular biology and cancer research.
ENY2, also known as enhancer of yellow 2 homolog, is a key player in maintaining genome stability and gene expression regulation. Dysregulation of ENY2 has been linked to various diseases, including cancer and neurological disorders, highlighting its importance in cellular homeostasis. Investigating the function of ENY2 is crucial for unraveling its role in disease development and for potentially identifying new therapeutic targets in the future.
Antibody Name:
ENY2 Antibody (PACO42214)
Antibody SKU:
PACO42214
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human Transcription and mRNA export factor ENY2 protein (1-101AA)
Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
Synonyms:
Transcription and mRNA export factor ENY2 (Enhancer of yellow 2 transcription factor homolog), ENY2
