ENTPD8 Antibody (PACO26497)
- SKU:
- PACO26497
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
ENTPD8 Antibody (PACO26497)
The ENTPD8 Polyclonal Antibody (PAC026497) is a crucial tool for researchers studying the ENTPD8 protein, an enzyme involved in nucleotide metabolism and cell signaling pathways. This antibody, produced in rabbits, exhibits high specificity towards human ENTPD8 and has been validated for use in Western blot applications.ENTPD8, also known as NTPDase 8, plays a key role in regulating extracellular nucleotide levels, which are vital for processes such as cell proliferation, differentiation, and immune responses. Dysregulation of ENTPD8 activity has been implicated in various diseases, including cancer and inflammatory disorders, making it a promising therapeutic target.
By utilizing the ENTPD8 Polyclonal Antibody, researchers can effectively detect and analyze ENTPD8 expression in different cell types, allowing for a deeper understanding of its functions and potential implications in disease pathology. This antibody is an essential tool for investigations in areas such as cell biology, drug development, and molecular medicine.
| Antibody Name: | ENTPD8 Antibody (PACO26497) |
| Antibody SKU: | PACO26497 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Ectonucleoside triphosphate diphosphohydrolase 8 protein (30-434AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot Positive WB detected in: Mouse stomach tissue All lanes: ENTPD8 antibody at 2µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 54, 50 kDa Observed band size: 54 kDa . |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO26497 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO26497 at dilution of 1:100. |
| Background: | Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP. |
| Synonyms: | Ectonucleoside triphosphate diphosphohydrolase 8 (E-NTPDase 8) (NTPDase 8) (NTPDase8) (EC 3.6.1.5), ENTPD8 |
| UniProt Protein Function: | ENTPD8: Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP. Belongs to the GDA1/CD39 NTPase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; Membrane protein, multi-pass; Hydrolase; Membrane protein, integral; EC 3.6.1.5Chromosomal Location of Human Ortholog: 9q34.3 |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q5MY95 |
| NCBI GenInfo Identifier: | 158705943 |
| NCBI Gene ID: | 377841 |
| NCBI Accession: | Q5MY95.2 |
| UniProt Secondary Accession: | Q5MY95,Q6UVZ0, A2BG17 |
| UniProt Related Accession: | Q5MY95 |
| Molecular Weight: | 49,393 Da |
| NCBI Full Name: | Ectonucleoside triphosphate diphosphohydrolase 8 |
| NCBI Synonym Full Names: | ectonucleoside triphosphate diphosphohydrolase 8 |
| NCBI Official Symbol: | ENTPD8Â Â |
| NCBI Official Synonym Symbols: | UNQ2492; GLSR2492; E-NTPDase; NTPDase-8Â Â |
| NCBI Protein Information: | ectonucleoside triphosphate diphosphohydrolase 8 |
| UniProt Protein Name: | Ectonucleoside triphosphate diphosphohydrolase 8 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Ectonucleoside triphosphate diphosphohydrolase |
| UniProt Gene Name: | ENTPD8Â Â |
| UniProt Entry Name: | ENTP8_HUMAN |
| Antibodies |
| ENTPD8 Antibody (PACO09105) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
ENTPD8 Antibody (PACO09105)
