Enpp1 Polyclonal Antibody (CAB17876)
- SKU:
- CAB17876
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | Enpp1 Polyclonal Antibody |
SKU: | CAB17876 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 580-730 of mouse Enpp1 (NP_032839.3). |
Sequence: | PIYN PSHP KEEG FLSQ CPIK STSN DLGC TCDP WIVP IKDF EKQL NLTT EDDD IYHM TVPY GRPR ILLK QHRV CLLQ QQQF LTGY SLDL LMPL WASY TFLS NDQF SRDD FSNC LYQD LRIP LSPV HKCS YYKS NSKL SYGF LTPP RLNR VSN |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | Pca; ttw; twy; M6S1; NPP1; Npps; PC-1; Ly-41; Pca-1; Pdnp1; CD203c; E-NPP1; E-NPP 1; 4833416E15Rik; Enpp1 |
Positive Sample: | HepG2,293T,Mouse kidney,Mouse liver |
Conjugate: | Unconjugated |
Cellular Localization: | extracellular region |
Calculated MW: | 103kDa |
Observed MW: | 120kDa/170kDa |
This gene encodes a member of the nucleoside pyrophosphatase/phosphodiesterase family of enzymes that catalyzes the hydrolysis of pyrophosphate and phosphodiester bonds in nucleotide triphosphates and oligonucleotides, respectively, to generate nucleoside 5'-monophosphates. The encoded protein is a type II transmembrane glycoprotein that negatively regulates bone mineralization. Mice harboring a nonsense mutation in this gene, termed tiptoe walking (ttw), exhibit ectopic ossification of the spinal ligaments. The encoded protein binds to the insulin receptor, inhibits downstream signaling events and induces insulin resistance and glucose tolerance. This gene is located adjacent to a paralog on chromosome 10. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 18605 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |