ENOSF1 Antibody (PACO58204)
- SKU:
- PACO58204
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | ENOSF1 Antibody (PACO58204) |
| Antibody SKU: | PACO58204 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:200-1:500 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Mitochondrial enolase superfamily member 1 protein (171-286AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO58204 diluted at 1:200 and staining in paraffin-embedded human endometrial cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO58204 diluted at 1:200 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion. |
| Synonyms: | Mitochondrial enolase superfamily member 1 (EC 4.2.1.68) (Antisense RNA to thymidylate synthase) (rTS) (L-fuconate dehydratase), ENOSF1, RTS TYMSAS |
| UniProt Protein Function: | ENOSF1: May regulate thymidylate synthase activity. Belongs to the mandelate racemase/muconate lactonizing enzyme family. ENOSF1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Mitochondrial; Isomerase; EC 4.2.1.68Chromosomal Location of Human Ortholog: 18p11.32Molecular Function: L-fuconate dehydratase activity; magnesium ion bindingBiological Process: cellular carbohydrate catabolic process |
| UniProt Protein Details: | |
| NCBI Summary: | This gene was originally identified as a naturally occurring antisense transcript to the human thymidylate synthase gene. Alternate splice variants have been described, one of which (named rTSalpha) represents an alternate 3'UTR that is complementary to the 3'UTR and terminal intron of the thymidylate synthase (TS) RNA and down-regulates TS expression. Other transcript variants (rTSbeta and rTSgamma) do not overlap the TS locus. The function of this gene appears to be primarily to regulate expression of the TS locus both via the antisense transcript as well as through the encoded proteins. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q7L5Y1 |
| NCBI GenInfo Identifier: | 74739173 |
| NCBI Gene ID: | 55556 |
| NCBI Accession: | Q7L5Y1.1 |
| UniProt Secondary Accession: | Q7L5Y1,Q15407, Q15594, Q15595, Q6ZS08, Q9HAS5, Q9HAS6 A6NMP3, A8K9R5, B3KSL6 |
| UniProt Related Accession: | Q7L5Y1 |
| Molecular Weight: | 24,284 Da |
| NCBI Full Name: | Mitochondrial enolase superfamily member 1 |
| NCBI Synonym Full Names: | enolase superfamily member 1 |
| NCBI Official Symbol: | ENOSF1Â Â |
| NCBI Official Synonym Symbols: | RTS; TYMSASÂ Â |
| NCBI Protein Information: | mitochondrial enolase superfamily member 1 |
| UniProt Protein Name: | Mitochondrial enolase superfamily member 1 |
| UniProt Synonym Protein Names: | Antisense RNA to thymidylate synthase; rTS; L-fuconate dehydratase |
| Protein Family: | Mitochondrial enolase superfamily |
| UniProt Gene Name: | ENOSF1Â Â |
| UniProt Entry Name: | ENOF1_HUMAN |