EDN3 Rabbit Polyclonal Antibody (CAB1045)
- SKU:
- CAB1045
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | EDN3 Rabbit Polyclonal Antibody |
SKU: | CAB1045 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 17-187 of human EDN3 (NP_996917.1). |
Sequence: | AGFV PCSQ SGDA GRRG VSQA PTAA RSEG DCEE TVAG PGEE TVAG PGEG TVAP TALQ GPSP GSPG QEQA AEGA PEHH RSRR CTCF TYKD KECV YYCH LDII WINT PEQT VPYG LSNY RGSF RGKR SAGP LPGN LQLS HRPH LRCA CVGR YDKA CLHF CTQT LDVS SNSR TAE |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | ET3; ET-3; WS4B; HSCR4; PPET3; EDN3 |
Positive Sample: | A-549 |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 25kDa |
Observed MW: | 44kDa |
The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 1908 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |