The Endothelin-1 Polyclonal Antibody (CAB0686) is a valuable tool for researchers studying endothelin-1, a potent vasoconstrictor and regulator of blood pressure. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in a variety of applications, including Western blot and immunohistochemistry.Endothelin-1 is a key player in the cardiovascular system, controlling blood flow and vascular tone. Dysregulation of endothelin-1 has been implicated in various cardiovascular diseases, such as hypertension, heart failure, and atherosclerosis.
As such, this antibody is essential for investigating the role of endothelin-1 in these conditions and exploring potential therapeutic targets.By targeting endothelin-1, researchers can gain valuable insights into the mechanisms underlying cardiovascular diseases and develop novel treatments to combat these prevalent health issues. The Endothelin-1 Polyclonal Antibody (CAB0686) provides a reliable tool for accurate detection and analysis of endothelin-1 in a wide range of experimental settings, making it an indispensable asset for cardiovascular research.
Product Name:
Endothelin 1 Rabbit Polyclonal Antibody
SKU:
CAB0686
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 18-212 of human Endothelin 1 (NP_001946.3).
This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1906
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Endothelin 1 Rabbit pAb (CAB0686) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
