The EMX2 Polyclonal Antibody (PACO03620) is a valuable tool for researchers studying EMX2, a homeodomain transcription factor known for its role in brain development and patterning. This antibody, raised in rabbits, is highly specific for human EMX2 and has been validated for use in immunohistochemistry applications. By targeting the EMX2 protein, this antibody allows for the detection and analysis of EMX2 expression in various tissues and cell types.EMX2 is a key player in the regulation of neural development, controlling the formation of structures in the brain and spinal cord. Research suggests that dysregulation of EMX2 expression may be linked to neurodevelopmental disorders and certain types of cancer.
Understanding the function of EMX2 is essential for uncovering its role in these conditions and exploring potential therapeutic strategies.Overall, the EMX2 Polyclonal Antibody (PACO03620) provides researchers with a valuable tool for investigating the functions and implications of EMX2 in various biological contexts, from neurodevelopment to disease pathogenesis. Its specificity and reliability make it a valuable asset for studies seeking to unravel the complexities of EMX2 biology.
Antibody Name:
EMX2 Antibody
Antibody SKU:
PACO03620
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the Internal region of human Emx2.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
EMX2; Homeobox protein EMX2; Empty spiracles homolog 2; Empty spiracles-like protein 2
UniProt Protein Function:
EMX2: Transcription factor, which in cooperation with EMX2, acts to generate the boundary between the roof and archipallium in the developing brain. May function in combinations with OTX1/2 to specify cell fates in the developing central nervous system. Defects in EMX2 are the cause of schizencephaly (SCHZC). Schizencephaly is an extremely rare human congenital disorder characterized by a full-thickness cleft within the cerebral hemispheres. These clefts are lined with gray matter and most commonly involve the parasylvian regions. Large portions of the cerebral hemispheres may be absent and replaced by cerebro- spinal fluid. Belongs to the EMX homeobox family.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 10q26.1Cellular Component: nucleusMolecular Function: protein binding; sequence-specific DNA bindingBiological Process: forebrain cell migration; neuron differentiation; response to drug; anterior/posterior pattern formation; dentate gyrus development; regulation of transcription, DNA-dependent; cell proliferation in forebrain; cerebral cortex regionalizationDisease: Schizencephaly
UniProt Protein Details:
NCBI Summary:
This gene encodes a homeobox-containing transcription factor that is the homolog to the 'empty spiracles' gene in Drosophila. Research on this gene in humans has focused on its expression in three tissues: dorsal telencephalon, olfactory neuroepithelium, and urogenetial system. It is expressed in the dorsal telencephalon during development in a low rostral-lateral to high caudal-medial gradient and is proposed to pattern the neocortex into defined functional areas. It is also expressed in embryonic and adult olfactory neuroepithelia where it complexes with eukaryotic translation initiation factor 4E (eIF4E) and possibly regulates mRNA transport or translation. In the developing urogenital system, it is expressed in epithelial tissues and is negatively regulated by HOXA10. Alternative splicing results in multiple transcript variants encoding distinct proteins.[provided by RefSeq, Sep 2009]
