The EMR4P antibody (PACO06458) is a polyclonal antibody that targets the CD300A protein, an immune inhibitory receptor crucial for regulating immune responses. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to CD300A, researchers can detect and analyze this key protein in various cell types, making it an essential tool for studies in immunology and cancer research.CD300A is known for its role in immune homeostasis, where it modulates inflammation and suppresses allergic reactions.
Its involvement in immune response modulation highlights its potential as a target for research into cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the functions of CD300A is essential for developing therapies that can manipulate immune function in these disease contexts. The EMR4P antibody provides a valuable tool for investigating the complex roles of CD300A in immune regulation and disease pathogenesis.
Antibody Name:
EMR4P Antibody (PACO06458)
Antibody SKU:
PACO06458
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IF
Recommended Dilutions:
ELISA:1:20000, WB:1:500-1:2000, IF:1:200-1:1000
Species Reactivity:
Human, Monkey
Immunogen:
Synthesized peptide derived from the Internal region of human EMR4.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of Jurkat K562 cells using EMR4 Polyclonal Antibody.
Western Blot analysis of COLO205 cells using EMR4 Polyclonal Antibody.
Function: Could mediated the cellular interaction between myeloid cells and B-cells By similarity.Subunit structure: Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit) By similarity.Subcellular location: Cell membrane; Multi-pass membrane protein Potential. Post-translational modification: Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit By similarity.Sequence similarities: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.Contains 2 EGF-like domains.Contains 1 GPS domain.Caution: Could be the product of a pseudogene. Seems to have became non-functional after human-chimpanzee speciation, about five million years ago.
