The EMR3 Antibody (PACO05532) is a polyclonal antibody designed for research involving EMR3, a cell surface molecule known for its role in immune regulation. This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in a variety of applications, including Western blot analysis. By binding to the EMR3 protein, this antibody enables the detection and analysis of EMR3 in different cell types, making it an ideal tool for studies in immunology and cancer research.
EMR3, also known as EGF-like module-containing mucin-like hormone receptor-like 3, is a receptor that has been implicated in immune responses and inflammation. Its involvement in immune regulation and inflammatory processes makes it a valuable target for research into various diseases, including cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the function of EMR3 is essential for developing therapies aimed at modulating immune responses in these disease contexts.
Antibody Name:
EMR3 Antibody (PACO05532)
Antibody SKU:
PACO05532
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IF
Recommended Dilutions:
ELISA:1:10000, WB:1:500-1:2000, IF:1:200-1:1000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the C-terminal region of human EMR3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
EMR3: Receptor probably involved in myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of momocytes- derived macrophages and activated neutrophils. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: GPCR, family 2; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 19p13.1Cellular Component: extracellular space; integral to membrane; plasma membraneMolecular Function: G-protein coupled receptor activity; calcium ion bindingBiological Process: G-protein coupled receptor protein signaling pathway
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]
