UniProt Protein Function: | EMR3: Receptor probably involved in myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of momocytes- derived macrophages and activated neutrophils. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: GPCR, family 2; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 19p13.1Cellular Component: extracellular space; integral to membrane; plasma membraneMolecular Function: G-protein coupled receptor activity; calcium ion bindingBiological Process: G-protein coupled receptor protein signaling pathway |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014] |
UniProt Code: | Q9BY15 |
NCBI GenInfo Identifier: | 133930786 |
NCBI Gene ID: | 84658 |
NCBI Accession: | NP_115960.2 |
UniProt Secondary Accession: | Q9BY15 |
UniProt Related Accession: | Q9BY15 |
Molecular Weight: | 6,996 Da |
NCBI Full Name: | EGF-like module-containing mucin-like hormone receptor-like 3 isoform 1 |
NCBI Synonym Full Names: | egf-like module containing, mucin-like, hormone receptor-like 3 |
NCBI Official Symbol: | EMR3Â Â |
NCBI Official Synonym Symbols: | |
NCBI Protein Information: | EGF-like module-containing mucin-like hormone receptor-like 3; EGF-like module receptor 3; egf-like module-containing mucin-like receptor 3 |
UniProt Protein Name: | EGF-like module-containing mucin-like hormone receptor-like 3 |
UniProt Synonym Protein Names: | EGF-like module receptor 3Cleaved into the following 2 chains:EGF-like module-containing mucin-like hormone receptor-like 3 subunit alpha; EGF-like module-containing mucin-like hormone receptor-like 3 subunit beta |
Protein Family: | |
UniProt Gene Name: | EMR3Â Â |
UniProt Entry Name: | EMR3_HUMAN |