The EMR2 Polyclonal Antibody (CAB14278) is a valuable tool for researchers studying EMR2, a cell surface receptor involved in immune regulation and cell adhesion. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the EMR2 protein, this antibody enables the detection and analysis of EMR2 expression in various cell types, making it an ideal choice for studies in immunology and cancer research.EMR2, also known as EGF-like module-containing mucin-like hormone receptor-like 2, functions as a receptor for adhesive interaction with cells expressing CD300 antigen.
It plays a crucial role in immune cell activation and migration, making it a key player in immune responses and inflammatory processes. Understanding the role of EMR2 in these pathways is essential for developing targeted therapies for diseases such as cancer, autoimmune disorders, and inflammatory conditions.Overall, the EMR2 Polyclonal Antibody (CAB14278) provides researchers with a reliable tool for studying the function and regulation of EMR2 in various biological contexts, leading to a better understanding of immune responses and potential therapeutic strategies.
Product Name:
EMR2 Rabbit Polyclonal Antibody
SKU:
CAB14278
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 300-500 of human EMR2 (NP_038475.2).
This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
30817
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using EMR2 Rabbit pAb (CAB14278) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
