The Emerin Polyclonal Antibody (CAB1132) is a valuable tool for researchers studying emerin, a protein found in the inner nuclear membrane that plays a crucial role in nuclear structure and function. This polyclonal antibody, produced using rabbit immunization, is highly specific to human emerin and is validated for use in various applications, including Western blot and immunofluorescence.Emerin is involved in various cellular processes, including gene regulation, DNA repair, and cell signaling, making it a key player in nuclear organization and stability.
Mutations in the emerin gene have been linked to Emery-Dreifuss muscular dystrophy and other genetic disorders affecting skeletal muscle function and cardiac health.By utilizing the Emerin Polyclonal Antibody, researchers can investigate the localization, expression levels, and interactions of emerin in different cell types and disease models. This antibody provides valuable insights into the function of emerin and its role in nuclear envelope dynamics, making it a valuable tool for research in cell biology, genetics, and muscular dystrophy.
Product Name:
Emerin/EMD Rabbit Polyclonal Antibody
SKU:
CAB1132
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human Emerin/Emerin/EMD (NP_000108.1).
Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene.
Purification Method:
Affinity purification
Gene ID:
2010
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Emerin/EMD Rabbit pAb (CAB1132) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
