The ELP6 Polyclonal Antibody (PACO52286) is a valuable tool for researchers studying ELP6, a crucial protein involved in RNA metabolism and gene expression regulation. This antibody, produced in rabbits, exhibits high specificity and sensitivity for ELP6 in human samples, making it ideal for Western blot applications.ELP6, also known as elongator complex protein 6, is a key component of the Elongator complex, which is involved in tRNA modification and RNA polymerase II transcription elongation. Dysregulation of ELP6 has been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting its importance in cellular processes.
By using the ELP6 Polyclonal Antibody, researchers can investigate the expression and function of ELP6 in different cell types and tissues, providing valuable insights into its role in disease pathogenesis. This antibody is a valuable tool for studies in molecular biology, cancer research, and neurobiology, facilitating advancements in our understanding of ELP6 biology and its potential as a therapeutic target.
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO52286 at dilution of 1:100.
Immunofluorescent analysis of PC-3 cells using PACO52286 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration.
Synonyms:
Elongator complex protein 6 (Angiotonin-transactivated protein 1) (Protein TMEM103), ELP6, ATP1 C3orf75 TMEM103
UniProt Protein Function:
TMEM103: Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration. Belongs to the ELP6 family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 3p21.31Cellular Component: Elongator holoenzyme complexBiological Process: positive regulation of cell migration
