The ELP5 Polyclonal Antibody (CAB14862) is a powerful tool for research involving ELP5, a key component of the Elongator complex that plays a crucial role in transcriptional elongation and tRNA modification. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the ELP5 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for studies in molecular biology and gene regulation.
ELP5 is a critical factor in the Elongator complex, which is known to regulate transcriptional elongation, tRNA modification, and various cellular processes. Dysfunction of ELP5 has been linked to neurological disorders, cancer, and developmental defects, highlighting its importance in cellular homeostasis and disease progression. Research into the functions and mechanisms of ELP5 can provide valuable insights into these conditions and potentially lead to the development of new therapeutic strategies targeting the Elongator complex.
Product Name:
ELP5 Rabbit Polyclonal Antibody
SKU:
CAB14862
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 17-316 of human ELP5 (NP_056177.3).
Predicted to contribute to tRNA binding activity. Predicted to be involved in positive regulation of cell migration and tRNA modification. Located in cytosol and nucleoplasm. Part of elongator holoenzyme complex.
Purification Method:
Affinity purification
Gene ID:
23587
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ELP5 Rabbit pAb (CAB14862) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
