The ELP4 Polyclonal Antibody (PACO09082) is a valuable tool for researchers studying the ELP4 protein, a component of the elongator complex involved in transcription and histone acetylation. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the ELP4 protein, this antibody allows for the detection and analysis of ELP4 in various cell types, making it ideal for studies in molecular biology and gene regulation.
ELP4 is an essential component of the elongator complex, which has been linked to various cellular processes, including transcription elongation, tRNA modification, and histone acetylation. Dysregulation of ELP4 has been implicated in diseases such as cancer, neurodegenerative disorders, and developmental abnormalities. Research into the function and regulation of ELP4 is critical for understanding its role in these conditions and for potentially developing targeted therapies in the future.
elongation protein 4 homolog (S. cerevisiae);ELP4;C11orf19;FLJ20498;PAX6NEB;PAXNEB;dJ68P15A.1 ;
UniProt Protein Function:
ELP4: Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Belongs to the ELP4 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 11p13Cellular Component: nucleoplasm; transcription elongation factor complex; Elongator holoenzyme complex; cytoplasm; histone acetyltransferase complexMolecular Function: protein binding; histone acetyltransferase activity; phosphorylase kinase regulator activityBiological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; RNA elongation from RNA polymerase II promoter; regulation of protein kinase activityDisease: Aniridia
UniProt Protein Details:
NCBI Summary:
This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants. This gene has also been associated with Rolandic epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
