The ELOVL3 Polyclonal Antibody (PAC022324) is essential for researchers studying ELOVL3, an enzyme involved in the production of very long-chain fatty acids, which play a key role in skin barrier function and lipid metabolism. This antibody, generated in rabbits, exhibits high specificity towards human samples and has been validated for use in Western blotting applications. By binding specifically to the ELOVL3 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an invaluable tool for studies in dermatology and lipid biology research.
ELOVL3 is crucial for the elongation of fatty acids, particularly in the skin, where it contributes to the maintenance of epidermal barrier integrity and hydration. Dysregulation of ELOVL3 function has been associated with skin disorders such as atopic dermatitis and psoriasis, highlighting its importance in skin health and disease. Investigating the role of ELOVL3 in lipid metabolism and skin physiology is vital for developing targeted therapies for dermatological conditions and understanding the link between fatty acid elongation and skin barrier function.
Antibody Name:
ELOVL3 Antibody (PACO22324)
Antibody SKU:
PACO22324
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:100
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human ELOVL3.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human placenta tissue using ELOVL3 antibody.
Background:
Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Highest activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs.
Synonyms:
Elongation of very long chain fatty acids protein 3; Cold-inducible glycoprotein of 30 kDa;
UniProt Protein Function:
ELOVL3: Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Highest activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. Belongs to the ELO family.Protein type: Membrane protein, multi-pass; EC 2.3.1.199; Membrane protein, integralChromosomal Location of Human Ortholog: 10q24.32Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membraneMolecular Function: transferase activity; protein bindingBiological Process: circadian rhythm; very-long-chain fatty acid biosynthetic process; triacylglycerol biosynthetic process; fatty acid elongation, saturated fatty acid; cellular lipid metabolic process
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein that belongs to the GNS1/SUR4 family. Members of this family play a role in elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides. [provided by RefSeq, Jul 2013]
