ELOVL1 Antibody (PACO42118)
- SKU:
- PACO42118
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
ELOVL1 Antibody (PACO42118)
The ELOVL1 Polyclonal Antibody (PAC042118) is a valuable tool for researchers studying ELOVL1, an enzyme involved in the elongation of fatty acids. This antibody, produced in rabbits, exhibits high reactivity specifically with human samples and has been validated for use in Western blot applications. By binding to the ELOVL1 protein, this antibody enables precise detection and analysis in various cell types, making it an ideal choice for studies in lipid metabolism and related research areas.ELOVL1 is a key player in fatty acid biosynthesis and has been linked to various metabolic disorders and diseases such as obesity, diabetes, and cardiovascular diseases.
Understanding the function and regulation of ELOVL1 is essential for deciphering the mechanisms underlying these conditions and developing potential therapeutic interventions. The ELOVL1 Polyclonal Antibody provides a reliable tool for researchers to explore the role of ELOVL1 in health and disease, paving the way for advancements in lipid biology and related fields.
| Antibody Name: | ELOVL1 Antibody (PACO42118) |
| Antibody SKU: | PACO42118 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Elongation of very long chain fatty acid, protein 1 protein (82-175AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescent analysis of MCF-7 cells using PACO42118 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human colon tissue using PACO42118 at dilution of 1:100. |
| Background: | Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acid, elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acid, /VLCFAs per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs. |
| Synonyms: | Elongation of very long chain fatty acid, protein 1 (EC 2.3.1.199) (3-keto acyl-CoA synthase ELOVL1) (ELOVL fatty acid, elongase 1) (ELOVL FA elongase 1) (Very long chain 3-ketoacyl-CoA synthase 1) (Very long chain 3-oxoacyl-CoA synthase 1), ELOVL1, SSC1 |
| UniProt Protein Function: | ELOVL1: Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids. Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Belongs to the ELO family. |
| UniProt Protein Details: | Protein type:EC 2.3.1.199; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 1p34.2 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; membrane Molecular Function:fatty acid elongase activity; protein binding Biological Process: fatty acid elongation, saturated fatty acid; linoleic acid metabolic process; sphingolipid biosynthetic process; very-long-chain fatty acid biosynthetic process |
| UniProt Code: | Q9BW60 |
| NCBI GenInfo Identifier: | 20137931 |
| NCBI Gene ID: | 64834 |
| NCBI Accession: | Q9BW60.1 |
| UniProt Secondary Accession: | Q9BW60,Q53HT2, Q5JUY3, Q8WXU3, Q9NVD9, Q9Y396, B4DP24 |
| UniProt Related Accession: | Q9BW60 |
| Molecular Weight: | 29,485 Da |
| NCBI Full Name: | Elongation of very long chain fatty acids protein 1 |
| NCBI Synonym Full Names: | ELOVL fatty acid elongase 1 |
| NCBI Official Symbol: | ELOVL1Â Â |
| NCBI Official Synonym Symbols: | Ssc1; CGI-88Â Â |
| NCBI Protein Information: | elongation of very long chain fatty acids protein 1 |
| UniProt Protein Name: | Elongation of very long chain fatty acids protein 1 |
| UniProt Synonym Protein Names: | 3-keto acyl-CoA synthase ELOVL1 |
| Protein Family: | Elongation of very long chain fatty acids protein |
| UniProt Gene Name: | ELOVL1Â Â |
| UniProt Entry Name: | ELOV1_HUMAN |
| Antibodies | ELISA Kits |
| ELOVL1 Antibody (PACO00755) | Human Elongation of very long chain fatty acids protein 1 / ELOVL1 ELISA Kit |
| Human Elongation of very long chain fatty acids protein 1 (ELOVL1) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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