The ELOVL1 Polyclonal Antibody (PAC022323) is a valuable tool for researchers studying ELOVL1, an enzyme involved in the elongation of fatty acids. The antibody, generated in rabbits, has high specificity for human samples and is validated for use in various applications including Western blotting. By targeting the ELOVL1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it suitable for research in lipid metabolism, obesity, and related disorders.ELOVL1 plays a crucial role in lipid biosynthesis and metabolism, making it a key player in the regulation of cellular lipid composition and function.
Dysregulation of ELOVL1 has been linked to various metabolic disorders, making it an attractive target for therapeutic interventions aimed at addressing obesity, diabetes, and other metabolic conditions. Investigating the function and activity of ELOVL1 is essential for gaining insights into lipid biology and developing effective treatments for lipid-related diseases.
Antibody Name:
ELOVL1 Antibody (PACO22323)
Antibody SKU:
PACO22323
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human ELOVL1.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HepG2 cells and Jurkat cells, using ELOVL1 antibody.
Background:
Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids (VLCFAs). Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.
Synonyms:
Elongation of very long chain fatty acids protein 1; ELOVL1; SSC1; CGI-88;
UniProt Protein Function:
ELOVL1: Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids. Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Belongs to the ELO family.
UniProt Protein Details:
Protein type:EC 2.3.1.199; Membrane protein, integral; Membrane protein, multi-pass
