The ELOVL1 Polyclonal Antibody (PAC016254) is a valuable tool for researchers studying ELOVL1, an enzyme involved in the synthesis of very long-chain fatty acids. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the ELOVL1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in lipid metabolism and related fields.ELOVL1 is a key player in fatty acid elongation pathways, with implications in various biological processes including skin barrier function, energy metabolism, and neurological development.
Dysregulation of ELOVL1 has been linked to conditions like ichthyosis and neurodegenerative disorders, highlighting its importance in human health. Investigating the function of ELOVL1 can provide insights into these diseases and inform the development of potential therapeutic interventions targeting fatty acid metabolism.
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela cells, A375 cells, Primary antibody: PACO16254(ELOVL1 Antibody) at dilution 1/550, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO16254(ELOVL1 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Elongation of very long chain fatty acid, like (ELOVL) proteins 1-6 are members of the ELO family of proteins, which play an important role in tissue-specific biosynthesis of very long chain fatty acid, and sphingolipids. The ELOVL proteins act as catalysts in fatty acid, elongation reduction and localize to the endoplasmic reticulum (ER). Elongation of very long chain fatty acid, protein 1 (ELOVL1), also referred to as Ssc1, is the human homolog of the yeast ELO3 protein. It is expressed in a variety of tissues and at especially high levels in stomach, skin, intestine, kidney and lung. ELOVL1 participates in the elongation of very long chain saturated and monounsaturated fatty acid, of up to 26 carbons and may be required for the development of a barrier in epithelial cells and skin. ELOVL1 is also important for the formation of Myelin in the central nervous system. Impaired ELOVL1 activity may be associated with disorders of sphingolipid metabolism.
Synonyms:
ELOVL fatty acid, elongase 1
UniProt Protein Function:
ELOVL1: Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids. Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Belongs to the ELO family.
UniProt Protein Details:
Protein type:EC 2.3.1.199; Membrane protein, integral; Membrane protein, multi-pass
