The ELOVL1 Polyclonal Antibody (PAC016253) is a valuable tool for researchers studying ELOVL1, an enzyme that plays a crucial role in fatty acid metabolism. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the ELOVL1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it well-suited for studies in lipid metabolism, obesity, and related metabolic disorders.ELOVL1 is involved in the elongation of fatty acids, a process essential for the synthesis of various lipid species that play key roles in cellular structure and signaling.
Dysregulation of ELOVL1 has been linked to metabolic disorders such as obesity, diabetes, and cardiovascular disease, making it a promising target for therapeutic interventions. Understanding the function and regulation of ELOVL1 is vital for developing strategies to modulate lipid metabolism and combat metabolic diseases.Overall, the ELOVL1 Polyclonal Antibody offers researchers a reliable tool to investigate the role of ELOVL1 in lipid metabolism and associated metabolic disorders, providing insights that could lead to the development of novel therapeutic approaches for these conditions.
Antibody Name:
ELOVL1 Antibody (PACO16253)
Antibody SKU:
PACO16253
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human ELOVL1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16253(ELOVL1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO16253(ELOVL1 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Elongation of very long chain fatty acid, like (ELOVL) proteins 1-6 are members of the ELO family of proteins, which play an important role in tissue-specific biosynthesis of very long chain fatty acid, and sphingolipids. The ELOVL proteins act as catalysts in fatty acid, elongation reduction and localize to the endoplasmic reticulum (ER). Elongation of very long chain fatty acid, protein 1 (ELOVL1), also referred to as Ssc1, is the human homolog of the yeast ELO3 protein. It is expressed in a variety of tissues and at especially high levels in stomach, skin, intestine, kidney and lung. ELOVL1 participates in the elongation of very long chain saturated and monounsaturated fatty acid, of up to 26 carbons and may be required for the development of a barrier in epithelial cells and skin. ELOVL1 is also important for the formation of Myelin in the central nervous system. Impaired ELOVL1 activity may be associated with disorders of sphingolipid metabolism.
Synonyms:
ELOVL fatty acid, elongase 1
UniProt Protein Function:
ELOVL1: Condensing enzyme that catalyzes the synthesis of both saturated and monounsaturated very long chain fatty acids. Exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Belongs to the ELO family.
UniProt Protein Details:
Protein type:EC 2.3.1.199; Membrane protein, integral; Membrane protein, multi-pass
