TCEB2 Rabbit Polyclonal Antibody (CAB5362)
- SKU:
- CAB5362
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | TCEB2 Rabbit Polyclonal Antibody |
SKU: | CAB5362 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-118 of human TCEB2 (NP_009039.1). |
Sequence: | MDVF LMIR RHKT TIFT DAKE SSTV FELK RIVE GILK RPPD EQRL YKDD QLLD DGKT LGEC GFTS QTAR PQAP ATVG LAFR ADDT FEAL CIEP FSSP PELP DVMK PQDS GSSA NEQA VQ |
Tested Applications: | WB IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | SIII; TCEB2 |
Positive Sample: | 22Rv1,NCI-H460,HL-60,SKOV3,MCF7,U-251MG,Mouse eye,Mouse intestine,Mouse kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 13kDa |
Observed MW: | 18kDa |
This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13.
Purification Method: | Affinity purification |
Gene ID: | 6923 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |