The Elongin A Polyclonal Antibody (CAB6994) is a valuable tool for researchers studying Elongin A, a key protein involved in the regulation of transcription and DNA repair processes. This antibody, produced in rabbits, exhibits high reactivity with Elongin A in human samples and is validated for use in Western blot applications. By binding to Elongin A, the antibody enables the detection and analysis of this protein in various cell types, making it an excellent choice for studies in molecular biology and cancer research.Elongin A is a component of the Elongin complex, which is involved in the regulation of RNA polymerase II transcription and the recognition of ubiquitinated proteins for degradation.
Dysregulation of Elongin A has been linked to various diseases, including cancer and genetic disorders. Therefore, understanding the function and regulation of Elongin A is crucial for developing targeted therapies and diagnostic tools for these conditions.The Elongin A Polyclonal Antibody (CAB6994) offers researchers a reliable tool for investigating the role of Elongin A in various cellular processes and disease states. With its high specificity and sensitivity, this antibody is an essential component of any research project aiming to uncover the molecular mechanisms underlying Elongin A function.
Product Name:
TCEB3 Rabbit Polyclonal Antibody
SKU:
CAB6994
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 679-798 of human TCEB3 (NP_003189.2).
This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation.
Purification Method:
Affinity purification
Gene ID:
6924
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using TCEB3 antibody (CAB6994) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
