Now, based on the provided URL, here is the product description:The ELMO3 Polyclonal Antibody (CAB7182) is a reliable tool for researchers studying ELMO3, a protein involved in cell migration and cytoskeletal rearrangement processes. This antibody is produced in rabbits and has been extensively validated for its specificity and sensitivity in various experimental applications, with a particular focus on immunofluorescence and immunohistochemistry.ELMO3, a key regulator of Rac activation and actin cytoskeleton dynamics, plays a crucial role in cellular processes such as cell motility, adhesion, and phagocytosis.
Dysregulation of ELMO3 expression has been associated with various diseases, including cancer and inflammatory disorders, highlighting its significance as a potential therapeutic target.By using the ELMO3 Polyclonal Antibody (CAB7182), researchers can accurately detect and study the expression levels and subcellular localization of ELMO3 in different cell types and tissues. This antibody enables detailed analysis of ELMO3 functions and interactions, providing valuable insights for further research in cell biology, cancer biology, and drug discovery efforts targeting ELMO3-related pathways.
Product Name:
ELMO3 Rabbit Polyclonal Antibody
SKU:
CAB7182
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 504-773 of human ELMO3 (NP_078988.2).
The protein encoded by this gene is similar to a C. elegans protein that functions in phagocytosis of apoptotic cells and in cell migration. Other members of this small family of engulfment and cell motility (ELMO) proteins have been shown to interact with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes.
Purification Method:
Affinity purification
Gene ID:
79767
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ELMO3 antibody (CAB7182) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 30s.
