The Elmo1 Polyclonal Antibody (CAB14830) is a vital tool for researchers studying the protein ELMO1, which is involved in various cellular processes including cell migration, phagocytosis, and immune response regulation. This antibody, generated in rabbits, is highly specific and reactive to human samples, making it an ideal choice for experiments such as Western blotting.ELMO1 is known to interact with the Dock180 protein to form a complex that regulates Rac GTPases, ultimately affecting actin cytoskeleton dynamics and cell movement. Dysregulation of ELMO1 has been implicated in diseases such as cancer, inflammatory disorders, and immune system dysfunction.
By using the Elmo1 Polyclonal Antibody, researchers can gain valuable insights into the function and behavior of ELMO1 in various cell types, contributing to advancements in immunology and cancer research.Overall, the Elmo1 Polyclonal Antibody is a reliable tool for detecting and analyzing ELMO1 protein levels, offering researchers the ability to further explore the role of ELMO1 in normal cellular processes and disease pathways.
Product Name:
ELMO1 Rabbit Polyclonal Antibody
SKU:
CAB14830
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 527-727 of human ELMO1 (NP_055615.8).
This gene encodes a member of the engulfment and cell motility protein family. These proteins interact with dedicator of cytokinesis proteins to promote phagocytosis and cell migration. Increased expression of this gene and dedicator of cytokinesis 1 may promote glioma cell invasion, and single nucleotide polymorphisms in this gene may be associated with diabetic nephropathy. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
9844
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ELMO1 Rabbit pAb (CAB14830) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
